The dies can be set for ether chamber. the main thing to know is which chamber you have. Both chambers are good but with the headspace issue it is important to at least know what you have.
Then the choice of which ammo to use is yours. Ammo varies in size and can work sometimes
without a problem and other times will cause issues.
The 280 AI is one of my favorite cartridges and it is a shame that it has been screwed with and
that it made things difficult for a great cartridge.
If anyone choses to shoot both sizes of ammo that is there choice, but just because they can get
away with it does not mean they should.
Even the first firing can be a problem if the Head space is wrong and with a potential of .014
thousandths head space it can cause case head separation or thin the brass to a point that failure will soon follow.
I recommend shooting the correct ammo (Don't mix Nosler with other brands)depending on the chamber specs. and sizing to fit your chamber. then it will last and be safe for many uses.
When firing any round, the head space should never be more than .006 to .007 thousandths.
Just a word of caution
J E CUSTOM