Absolutely . i have taken many elk with 260 Rem, 6.5x55& 6.5-06. Barnes 120gr TSX/TTSX. Complete penetration thru both shoulders. Also deep penetration from front & back at extreme angles. Worst bullet I've seen used on elk is the Hornady 143gr ELD-X. Thru the rib cage is OK. Thru a meaty area they blow up like a bomb & destroy large amounts of precious meat.