You'll love the 25-06. Hard to beat for varmits to Mule Deer. It has laser like trajectory, is typically super accurate and also easy on the shoulder. As a previous poster stated, 300 yards is where it begins and not ends, with the 25-06. Don't let the 6mm crowd sway you with the bullet selection argument. Truth is, unless your shooting past 500 yds, bullet BC's don't make much difference.
Not a fan of the Ackley. Imo, too much work and not enough reward, unless you like to tinker and or have plenty of spare time to dink around fire forming. If you want more velocity, step up to the 257 Weatherby.
My favorite powder, hands down is H4831sc, with either the 100 Ballistic Tip or 100 Sierra Pro Hunter. The 100 Pro Hunter is not a fancy bullet, but boy is it accurate and kills like lightning. Don't have much experience with the 110-120 gr bullets. The 100 gr bullets imo, provide the most versatility.
Good luck with your decision.