YES! That is why my 358 Winchester with 200g Sierra RN bullets puts them on the ground: big hole on both sides, lots of blood if there is a bit of a run. 200yds is about my limit distance.I want an exit, but not just falling out. Bullets create shock ONLY when they are going fast enough to create that pressure and force in the tissue. When a little expanding Bullet hits flesh, it immediately Slows down. Most deer caliber bullets cant even create a wide shock path longer than a few inches. Try some ballistics gel and see it. It's a short length of shock, then a pencil thin hole the rest of the way out. Sure that's normally enough to make the kill, but I want 6" diameter+ shock cavity the entire length of the wound channel, regardless of point of impact. Big bores, heavy flat nose bullets, high bullet speed from entry to exit with large frontal area makes fast kills and covers for a lot of my human error at the shot. I use expanding bullets for longer range, but I still pick a bigger gun than most so I can use a sturdier bullet with softer nose to create the same effect. At least that's my experience.