I've killed 74 deer and 3 hogs in the last two months with a 6 creed. Kissing cousin to the 243. These have been 100 pound avg deer. Used 3 different bullets. It isn't even close to being in the same class with a 25, 6.5, 270 or the like. Even the 6.5 Grendle kills better. With 243/6mmyou get more runners, less blood, longer runners, more lost animals. Seen it not only this year but all my life. Tracked or used my tracking dog on many animals shot with 243. I was elated when they moved up to a bigger cartridge because the adventures in tracking went down. It's a fairly decent cartridge for what I do with it, depredation. Or coyotes. No way in h-ll I'd shoot trophy animals with one.