What rifle are we talking about here? That'll make a huge difference, and the various 4350s may not be a problem at all for you. I suspect that you're saying this due to hearing about the powder limitations for reloading 30-06 ammo for the M1 Garand? If so, please understand that the limitations there are due to the rifles's design, not the caliber. The M1 was set up to function with standard USGI ammunition, loaded with anywhere from 150 to 173 grain bullets, using powders not slower than 4895 or 4064. In other rifles with different gas systems, a slower powder may not be an issue at all.
So, which rifle are we talking about?