In My 270 WM I use the Hornady 130 and 150 Spire point, reason being that they are 2 of very few bullets that shoot real good in my rifle . Not sure why others do not, but these two do. I would recommend you use controlled expansion bullets due to the high velocities this cartridge generates. As far as powder goes i've had good results with RL-22, IMR 7828, Norma MRP and the discontinued H-450. RL-26 also gave me decent results but I did not do much load dev with it. I've also had best results with the Fed 215 primer and Weatherby/Norma brass.