There is quite a range of prices for the presses which can handle the .50 BMG.
Midway has a sale on the LEE Classic Cast for .50 BMG:
Kit Includes: The Classic Cast Press, 50 BMG die set, shell holder, ram prime and case lube. Also includes large and small primer arms as well as a die bushing for reloading with standard 7/8 x 14 thread dies.
$239.99
https://www.midwayusa.com/product/1013021327
RCBS makes a bundle with everything you need to reload the .50 BMG case between $550 -750.
Hornady makes the Lock-n-Load similar pricing
I started with the RCBS AmmoMaster because I got it in a good deal. But last year I switched to the Turban Prazipress Heavy press (Germany) since I was working with the larger cartridges more frequently. Now I have the Talon Advanced Precision press on order from Italy because I need another large press.
The Prazipress and Talon are not for the faint of heart unless compared to what you might find to be acceptable from Chinese castings assembled in America by RCBS and Hornady.
https://www.solidsolutiondesigns.com/product/reloading-press-talon-advanced/
http://www.turban-cnc.de/about-us-2