The last two builds I have done with HBN I did not do my normal barrel break in period, just started load development with HBN coated bullets. I noticed zero difference from doing your standard barrel break in procedure and then starting load developement, other than I saved some components. Load work up was consistent and I did not notice any major change. They slowly got faster for the first 40-60 rounds or so, but only a total of around 25 fps. It likely has no scientific merit, but it makes me feel warm and fuzzy knowing that every bullet fired has had HBN, so the bare, virgin bore was impregnated well with the stuff.
The rifles were a .264 win mag in a Krieger barrel and a .338 Norma in a Carbon Six barrel. The .264 wm has right around 100 rounds through it, and still no copper fouling is visible. The .338 Norma has around 80 rounds with the same result. Both shoot ridiculously well.