I shot an antelope with a 300 Berger from my Edge this past August; went thru him with a 2" exit hole. Still ran 150 yards.
The one bullet I have lost confidence in a the Barnes. I shot a grizzly bear a few years ago right behind his front leg as he was quartering away. His right leg (opposite side) flew up in the air and smacked to the ground, only to get up and run into a massive alder patch (like kilometers wide and long). It was very near dark, so my guide said we would return the next morning to fetch him. That night it rained all night and the only blood we found was on an upside down leaf.
I thought maybe I hit him too high. Eight months later I took a shot at a kudu with the same load. Kudu didn't flinch. PH said, "You hit him good, just wait."
Kudu starts to feed a bit, then walks away. PH says shoot him again, so I did and he dropped. When we skinned him we saw the Barnes completely penciled through its lungs. Made me wonder if that is what happened to my grizz bear the fall before. Who knows? That
same bullet, a 225 .338 Barnes, has killed an African lion and leopard in Tanzania (pretty soft) as well as all kinds of plains game in three other Tanz hunts, two in Namibia, one in Zim (although I did shoot my leopard on that hunt with a Hornady 225 cup and core), a pile of 6x6 elk, four moose in AK/BC and the Yukon, and god knows what else.
Y
I guess if you hunt long enough, s*&t happens.