It certainly is twist dependent. My Remington 700 .223Rem with 1:12 shoots 60gr Nos BT very well but 62Gr tumble like a weed.I think the best decision for a recreational shooter/hunter is to chose the faster twist for a cartridge. My meaning is, for a .308, use a 10 twist. For .223, use a 9 twist. 7mm, try the 9/10 whichever is available. All those barrels will pretty much shoot the mid to heavier for caliber bullets. Not the heaviest but typically those are specialty bullets for specific use. The faster twists above that I mentioned will stabilize the lighter bullets also. It gives a wider range of bullets to use rather than only light bullets having a slow twist barrel. My 22-250 with a 14 twist barrel shoots the 40 grain bullets extremely well. My 8 twist 22-250 AI shoots the same 40 grain bullet good but not quite as good. The 14 twist will not shoot a 69 SMK at all. Tumbles all the way to the target. The bullet selection is much narrower with slow twist barrels vs faster twist tubes.