The 257 Wby shooting 100 grain bullets at 3760 fps, 257 STW with same bullets in the 3800's are good for this type set up. The 300 RUM shooting 150 grain bullets around 3700 fps is also good. At 5000 feet elevation where I live you can zero these 3 1/2"- 4" high at a hundred with a mid range trajectory of 6-6 1/2" and be around 20" low at 600 yards which is very easy to figure. They make kills trivial out to 600 yards or so and I use that set up for beginniers often. You must have a bipod or good rest and get set up for any shot. Light bullets traveling very fast are good to this range. Beyond and they just drop off the table and the wind takes them for a ride.