I have had good results with Imr or H 4350 in hunting weight bullets(95 and 100gr) and H414 or H4064 with the light varmint weight bullets. My last load I hunted with was with 95grain nosler ballistic tips and Hodgdon H1000 powder. I don't remember how many grains of powder, but you can find it on their site. It was a compressed load which grouped well and had very consistent velocity. I have shot deer with 100 grain nosler partitions, sierra boat tails, and some early barnes bullets way back when. With good shot placement all will work well, the partition held together when best you hit heavy bone. I shot a deer at 400 plus about 15 years ago and took him with one shot through the lungs. It's a great caliber for varmints to deer, and for young shooters as well.