This is about what everyone is saying, not that it just won't kill 'em at all.. . . most all around or under 200yds. . . .
I am thinking of buying a 22-250 for varmint hunting but was wondering if it is usable for antelope? I was also thinking of a .243 but that would be overkill for coyotes.
Would the larger grain bullets work in a factory twist?Yes and no. An off the shelf 22-250 will work fine for varmints, and also work on deer depending on how far you want to shoot them. If you want a 22-250 to kill goats at distance, you will need to build and shoot heavy bullets. 80 grain smk's do the trick, and I've also seen 90 smk's down a few goats. As stated the 6mm will so better in the wind, but a 22-250 shooting 80's is a different animal than shooting 55 class bullets.