The odds are, you could shoot every stinkin' one of them and never even flatten a primer.
But what are the
stakes you're playing with?
You have one "unknown" in your equation. So ... what do you have to lose?
Those loads may have been through gun shows, estate sales, yard sales, bad storage ... yeah, I've got some loose stuff like that too. If you had the original loader by the ears, he probably wouldn't even remember. [Or even admit to it!] The 22-250's been around for a long time.
If you don't want to pull those bullets, it's easy for
me to say "pull those bullets" and move on. But shooters and handloaders are obsessive about salvaging little bits and pieces that mean nothing. If they were mine, I'd dump the powder in the burn pile and say "Thanks!" for the other components. As you know, smokeless powder burns slowly in the open ... blackpowder goes up with a "Whoof!"
Speaking of which,
SOMEbody tossed ... must have been about 500 old primers ... onto
my burn pile last year. When things settled down toward the fire bed, they sure were a'poppin'! We retired to a respectful distance and speculated about which of our friends/neighbors might have that kind of humor! Nobody got hit by a flying primer, but it sure was a ...
"crackling" fire!