I appreciate your feedback indeed ! D.CCI 450s should do just fine in a 22 Creedmoor. I use 450s in dasher and 25 Creedmoor up to 43gr of either h4350, h4831, or RL16. Never experienced a misfire of any kind using those loads. Accuracy and consistent speeds were normal even in sub freezing temps with rifle and ammo freezing cold.