Depends on what you call acceptable. One particular powder will not necessarily produce the lowest Sd, or even acceptable accuracy in a different rifle, or even with a different bullet lot in the same rifle. I have duplicate rifle chamberings in a handful of popular ones. 6.5 Grendel, 5.56, 308, 30/06, 264 win, 30/338 win...
A particular load that yields an SD of 8 in one of my 264 win rifles produces an SD of 29 in one of my other 264 rifles and 15 in another, in the fourth rifle it had a nasty bolt lift and isn't what I would consider to be safe.
Varget works best in one of my 308 rifles with a 167 Lapua, but doesn't shoot 2 MOA in another. IMR4166 works best with a 185 berger juggernaut in that rifle and R-15 will nearly match the accuracy of the Varget load in the other rifle with the same 167 Lapua, brass and a different primer. However it isn't nearly as temperature stabile.
Once I find a load that shoots well in a particular rifle I buy enough of those components to wear it out, or last a couple of years in the rifles I shoot a high volume. I shoot some three gun matches around where I live and don't want to miss a match because I ran out of the load I use in my 5.56 or 308 and find out that a particular component is out of stock.
When I get another rifle in a particular chambering I work up to try the existing load from the other rifle, which logistically would be ideal, but it hasn't worked out for me yet. My 5.56 rifles come pretty close, and two of my 308 gas guns can run the same load at close ranges but anything beyond 300 and one of them isn't happy, and neither am I.
