I used Hornady 350gr with IMR3031. But that was over twenty years ago. There's probably better loads out there now. The guide said he never saw a caribou go down so hard. Around a 50 yard running shot.
That still works.
The OP has realistic expectations with a 150yd gun. Now you need to decide whether or not you need to kill T-Rex or just deer.
I've got two 45-70s, one is a C Sharps that I only shoot Holy Back and galena the other is a Miroku Winchester Highwall with a 24" barrel. I've run that one up to slobber knocking 2400FPS with 350s. In a rifle that weighs less than 9 lbs that will give you all the fun you need in a short time. You should do it once and if you don't separate a retina or loosen fillings you'll have had enough and you can get to a load that makes sense. (I did)
These days I run my loads in the range of 1600 to 1800FPS depending on the bullet. i shoot Sierra and Hornady 350s and Remington 405s with IMR 3031. It will shoot though just about anything in North America from any angle at reasonable ranges.
I tried a lot of powders, a whole lot of powders when I was experimenting. Acc 5744, Rx7, and IMR3031 are the best options that I found with smokeless. The case is designed for black powder, and it is way over capacity for smokeless. Don't be tempted to try the slower powders in the range of Varget. You'll have unbruned powder in the bore, the pressure never gets up enough.
Get a Lyman reloading manual. It has a lot of good loading info for the 45-70 with smokeless.
I'd advise either getting a scope like the Swaro Z3 with the BRH retical or something similar. The drop on a 45-70 is dramatic past 100 yards. Depending on your load it's 18-24 inches from 100 to 200 yards. I have to look but I think my load works out to dropping ½ mil per 25 yds from 100 to 200, which works great in the BRH since it's got dots or hashes ever ½ mil.