If you want to zero at 100 you can run up to 1/2 the amount of travel available in your scope. eg: If you have 120 moa in the scope you can run 60 minutes of base. This will allow you to use all the internal travel of the scope.
Alternatively if you want it's possible to exceed this number and run a zero offset. Tons of guys that shoot ELR will run a base that does not allow them to come to a true zero at 100, they then enter into their solver how many inches high at 100 to allow them to extend farther out.
If I was going to run a zero offset I would decide what's the closest target I intend to shoot with that rifle. Say 1000 yards, figure out my dope for that. Call it 20 MOA, and my scope can handle a 60 MOA base so that puts me to a 80 MOA base and will give me crosshairs on target at 1000 Yards and I can dial up from there.