Believe it or not, everything about firearm design/ballistics/results, begins with a chosen bullet.
That is, for the best in results a chosen bullet affects the entire design of the shooting system, and of coarse the bullet choice is tied to application. Your potential is immediately set.
For example;
If you need to kill brown bears, your not going to put together a shooting system -with needed bullets, that will shoot anywhere near the accuracy possible from little mid-weight flat base bullets used in point blank BR. You can try it, or look around and notice NOBODY has ever pulled it off.
There are a bunch of reasons for this, and BC resulting can be little more than a side effect of design, or a major factor in real world LR accuracy.
A few factors to consider;
Admit right up front that you cannot call and hold-off for wind perfectly over distance shooting. With this you add hold-off error to the gun's potential in MOA of accuracy.
Now a 1/2moa gun at 300yd rarely produces 1/2moa at 1kyd. And you could not produce 1/2moa at 1kyd, in any wind, with a 1/8moa shooting 6PPC(wrong bullets). This is why nobody competes at 1kyd with THE cartridge widely implied the most accurate in existence(6PPC).
With High BC bullets the penalty for wind miss-hold is reduced, taking you back towards the gun's actual accuracy potential. It's the reason LR BR shooters universally use heavy for cal hi-BC bullets(whether they know this or not). They don't use these bullets because they're the most accurate(they aren't).
Why aren't hi-BC bullets more accurate? Well, BC=weight=recoil, which does nothing good for accuracy. BC=Boat tail=lower quality muzzle release, which is factor causing bullet moments to dampen out(go to sleep). That ain't great for accuracy either. Take 2 bullets of the similar ogive radius, and same weight, but one flat base and the other boat tails. Same barrel and tuned seating depth.
The flat base bullets will shoot better -up close(like 300yds) despite the cost in BC.
And you will shoot with better results at 1kyd with the higher BC boat tail bullets, way more often.
Terminal performance is another really important consideration.
But personally, I take accuracy over terminal performance. 2yrs ago I comfortably took a white tail with a 50gr flat base BR bullet(Jayner) out of a 223rem at 485yds(brain shot). This, with my son's Cooper. In no way is this a preferred setup for LR shooting(or for deer), and I limit my shots with it to 500yds even if calm.