I have used the barnes in the following:
6 Remingon, 85g Barnes TSX, hot load of R19 at 3400 fps
243 Win,l 80g TTSX, IMR 4064, 3400 fps
270 win, 110g TTSX with Win 760 and R#17, 3275 fps
7 rem Mag, 120g TTSX with R22
140g TTSX with IMR 4350 and R19
7 STW with 120g ttsx at 3850 with R22 and IMR 7828
I jumped the bullet .050 from the lands in each caliber, never altered getting excellent accuracy of less than 1/2" groups. The 7 STW with the 120g TTSX shot 1/4" groups at 3850.
I had great results on all of these loads on deer.
For me, the 80g ttsx re defined the 243 Winchester, amazing results on deer, just jump them .050 from the lands, and I use standard loads for the 80g Sierra Blitz boat tail. We skin all of our deer, lung/heart is a blended mess if you like lung shots.