I've only shot one buck with it, this columbian blacktail was 300 yards lasered, quartering heavily away. I was on top of that hill in the background. The bullet hit the near lung, crossed through the neck vertibre dropping the buck instantly, and stopped under the far side neck skin.
I loaded some 69gr Absolute Hammers but abandonded them after failing to easily find a good load. They shot terrible for me. I need to try again.
Primary use for my 6DRI is on predators with a 55gr NBT-lead free @ 3550 fps. It's a hammer! Instant kills no exits, super accurate.