Gurn,
Straight answer. What the rifle likes. Same for seating depth. On our website under information go read 'VLDs, making then shoot". You want to find the seating depth sweet spot first at the lowest powder charge listed for the bullet/powder/cartridge combination you are testing. Once you've found that. Work you load back up slowly checking for pressure signs and accuracy as you increase your powder charge. There are no magic velocities or seating depths that you can just plug and play. Test.