Over the decades, I've loaded many, many thousands of varied magnum loads for handguns and carbines, and the vast majority of those loads, cast and jacket, were loaded using standard primers. If a mag primer gave better groups, then I would use it, or if I was hunting in very cold temps. Blue Dot, 2400, H110, 296, Lil'Gun and a few surplus powders have all been ignited by varied standard primers. I can't recall every having one that did not ignite. YMMV