Very soon, I intend to begin an experiment that, for me, will enter uncharted waters. I am going to experiment with some 300g Cutting Edge bullets in my .375 H&H. It is a CZ 550 with 25 1/2" barrel. According to Hodgdon's reloading data, a max load of H4350 will produce 2640ish fps from a 24" barrel. Considering that Hodgdon shows the best velocity with 300g bullets to be produced by 4350, would RL17 be worth a try in an attempt to eek out some extra velocity? Does anyone have enough load development experience with this cartridge to have a good idea of what powders produce the best velocity with heavy bullets? I realize that the good ol' H&H isn't considered a hot rod cartridge in any circles. I am curious, though, what kind of potential it would have with high bc bullets. I am interested in learning something about the max potential of this cartridge. I think a lot of whether or not this idea is a success will depend on how fast I can safely push heavy bullets and where the accuracy node falls in my rifle. Because I only have 50 of the Cutting Edge bullets, I will have to be efficient in my testing. I expect to be able to establish my max and find my accuracy load in 30 rounds or less with a single chosen powder, since I won't have to tune the seating depth with these bullets. That will leave me 20 rounds for testing to 600 yards (which is the longest range I have access to). I have some 300g Hornady Spire Points that I am thinking of using only to test the velocity potential of different powders. Once I have identified the powder with the best velocity potential, I would then use that powder in load development with the CE bullets. I am currently considering H4350, RL17, and Vihtavuori N540. I would appreciate any suggestions, advice, or criticisms of my thinking and planned methodology on this. I need to make every shot count, so it is important that I have a well thought out plan of attack when I get started.