It all depends on what game you will be shooting and what distance you plan on shooting that game. 400 yards and in on deer size game a good 150 gr bullet like the Nosler BT or Sierra SP or Hornady SST and 43 to 44 grs IMR 4895 has accounted for a good deal of deer for me. As of the past few years where I hunt with my 308 Win for deer the shots are not much over 300 yards and most between in your lap out to 200 yards. I have gone to this load. 46 grs IMR 4895, WW case, CCI-Br2, 125 gr Nosler Ballistic Tip and it does 3000 fps from my 21 1/2" Heart barrel 700 Rem. IT SMOKES DEER. If you keep the impact velocity under 3000 fps the 125 BT is awesome on deer. I shoot it in my 30x47 rifle at 2850 fps and my T/C Contender 14" barrel pistol in 30-30AI at 2670 fps. Put one in a deers shoulder and it goes BANG FLOP. If your shot will be 300 to 600 yards or so I would go with a good 165 gr bullet or one of the Berger VLDs around that weight. As for brass. If I could not find new cases. If it were I would start with the newest cases I had. Preferable once fired full length sized all the same head stamp trimmed and match prepped by doing the inside flash hole, primer pocket and weight shorted.