I have shot the 22/250 and AI for decades on coyotes, shots were 350 yards and under. I shoot the 55g with a MV of 4050 fps with Win 760 or AA2700, 50g Ballistic tips at 4200, and coyotes died quickly. We had to take shots on running, trotting, and walking coyotes, and very often you do not leade them enough and hit them in the stomach and hindquarters. You need the speed to do some terrific damage so they are planted in their tracks. I had more flippers, spinners, and floppers with the std 22/250 than the AI version, and I cannot stress this enough....55's. I saw diminishing DRT coyote kills when hit in the stomach at distances of 250 yards and further with the std. 22/250. Back then, we hunted in Mexico with proper gun permits and hunting licenses, that ended in 1991 when the New President of Mexico passed a law that all Americans had to have a Mexican Guide with them.
I fire-formed cases with 55s at 3850 on hair, or fire formed with 14g of bullseye and cream of wheat. We Also shot the 60g Berger Hp with 37g of Win 760 at 3700 fps, and this load just massacres a coyote, I shot a bobcat in half with this load, around 100 yd shot as he sat on a pond dam watching fish.
Almost everyone is using heavy bullets these days, and I am slow to jump on board with slower, less flat shooting trajectories as most of my shots are 325 and under. I rarely ever hunted in the Plains states where wind howls and distances are great, the exception being prairie dog towns.
The 22/250 AI and the Creed are kiss'en cousins. When you stand a creed case up against the 22/250 AI, they look like twins, with one having a sharper shoulder angle. I have not measured but the CC capacity in water between the two can not be much at all.
If I were in a debate with myself on which to choose, if either one did not have enough power to suit me, I would opt for a 22-243 AI and I have two of these in slow twists where I shoot the 60s at 4000 fps in the 23" Hart 14T. I have not chronographed the 14T, 26" yet. Be forewarned that many of the reamers on the gunsmith's toolboxes do not work with Lapua brass, it is much fatter in the web than Winchester/Rem brass. I neck turn all my necks for the 22/243 AI, with amazing accuracy with the 60g Sierra. 55g bullets did not work worth a darn in the 22/243 AI and I blew the primers out of the pockets using varget, as the powder demonstrated to have an incredible pressure spike on the top end. Win 760 in the 22-243 AI proved to immediately shoot bug hole groups with few rounds fired with 60g Sierras shooting groups in the 2's.
In our Predator calling club, there were at least a dozen guys shooting the 22/250 AI, pretty much the same load of 55g what evers, 44.5g of Win 760, Federal 210 primers with 1/2" groups at 200 yards being the norm.
In today's world, the 22 Creed would be attractive but don't deceive yourself into thinking that it is a more potent case than a 22/250 AI, brass brands being equal.