To each their own, but the Natives I know don't miss.
Shoot what ever you can shoot well. But remember that little guns have very little energy. I am a serious wolf hunter and trapper. My wolf gun is a 338 Lapua mag. Plus I always carry my 44 mag. Getting a clean standing shot under 200 yards is not the norm. More like 500 to a 1000 yards across a canyon.
Hey, r u da guy I red about in what was it? Zane Grey, North of some thin'??
Ubetcha!!! The 250 is plenty for wolf. Especially with the fast twist and heavy for cal bullets. The only real benefit of the heavy projectiles is longer range and improved wind handling.
Any bullet the 250 will shoot well will do the job.
Shot placement, as always, is king. But, keep in mind that their heart is just behind the last rib. If you want to take one home move the shot a bit more forward. Think bait about that one.
A local just received his Montana Rifle in 220 Swift as his wolf rig.
Good luck on your Woofin'.