I travel from Texas to hunt out west. The two biggest variables in the equation will be the air density for lack of a better term (altitude) and the temperature. They work in opposing ways and often cancel each other out or make the change so small it isn't a factor until you cross 500+. Example- I do my load development and zero during the summer in Texas- Temps when I'm shooting in the early AM are often 80+ (less dense air) and I'm at less than 1000ft MSL (more dense). When I hunt in OCT/NOV out west it is often much colder (more dense air) but I'm at higher altitude (less dense air). So they often come close to cancelling each other out. So- I will sight in my rifle with a no BS 250 yard zero and record the exact conditions in Texas. Then I go to my ballistic app and I change my temp and altitude to my expected hunting conditions and I measure the differences between my drop charts for each. I often find there is very little difference between the two at the ranges I am comfortable shooting at a game animal (500<). I still confirm my 250 yard zero upon arrival at my hunting destination and then I plug in my current conditions and recheck my drop charts. Hope this helps!