For deer size game I have two loads that I have used for years.
44 grs IMR 4895, Federal (turned neck) cases, CCI BR-2 primer, 150 Sierra Game King.
This is the load that I use for under 300 yards on deer.
46 grs IMR 4895, WW case, CCI-BR2, 125 Nosler ballistic tip. Wicked on deer.