Years ago... I was struggling to find a reasonable maximum chamber pressure for my 357 Herrett. I was using a Super 14 Thompson Contender and since it was (is) a Wildcat cartridge, there is no SAAMI pressure standard. You'll find 35,000 psi bandied about.
The parent cartridge for the 357 Herrett is the Winchester 30-30 (SAAMI MAP 42,000 psi). Now, I am a firm believer in common sense... and Ocam's razor, so I calculated the Bolt Thrust for the 30-30 Winchester and developed loads for my 357 Herrett that did not exceed the Bolt Thrust pressure determined for the 30-30 Winchester. This pretty much matched the MAP. I did this a long time ago and have shot a lot of IHMSA events using my Herritt at near maximum velocity (i.e. chamber pressure). Enough to develop a very good level of confidence about what is going on. AND... I have no frame stretching.
I believe that the critical thing about the whole pressure issue is Standard Deviation. If you load to an average chamber pressure, half the loads will exceed that pressure. The critical question is, "By how much?" Your Standard Deviation will tell you that... and you must use 3 SIGMA precision to get those outliers. Since SAAMI usually tests to 130-150% recommended chamber pressure, small fluctuations may... MAY... be trivial. Your primers will whisper to you, so listen. Your firearm will whisper to you, so pay attention. The voice in the back of your head will whisper, too... so, for God's sake, pay attention. If your primers are screaming at you, you're not paying attention to something important. We call that being, "dumb." Don't be dumb.
So, I have developed a method that I believe is safe and reasonable to adjust maximum chamber pressure when needed. In my example above, I use 42,000 psi as the MAP for my 357 Herrett. That is the the upper pressure for 3 SIGMAs of Standard Deviation for my muzzle velocity. I get about 10 fps SD on my Herrett loads... so I adjust my powder charge to never exceed 30 fps above my maximum load. That easily converts to a maximum powder charge. But, watch your station temperature.
I believe that this process will work for other loads, too. I am also overly curious and I am always "what if'ing"... but, I have all ten fingers and both eyes after 50 years of reloading and experimentation.
Best regards