I haven't tried them in my std. 280 but I have in my 280 AI with 63 grains Retumbo and have had excellent results both in the field harvesting a nice White Tail Buck exit wound size of a hardball and at the range with groups in the .2 range ! You could also try H1000,H4831, Hybrid 100 V or even WWSupreme 780 with the 168 Berger VLD.
Good Luck.
gun)