As was said, could be a lot of things. Rifle bedding has issues, action screws coming loose, scope base screws loose, scope ring caps coming loose, not enough torque on the rings, too much torque on the rings, front scope base screw too long and hitting barrel tennon, scope itself having problems, muzzle brake loose, paralax not properly set, inconsistent shooter form, inconsistent trigger press, not enough trigger overtravel, trigger pins contacting bedding, barrel not floated, and that is just some of the possibilities with just the rifle and shooter, without even getting into load developement......
If you are 100% sure the rifle system is sound, as in you have another load that is known to shoot well and is still shooting, and your also sure that you didn't pull the shot, then there is a problem with the load, and if that is 100 yards, it seems to really not like it. Also, that is a huge e.s., I would look for a node in a different velocity range, likely higher with that bullet weight and chambering, and depending on what you have tested in the load, check the affects of different primers.