At the velocity you mentioned, I still go for the shoulder shot, even with the Berger VLD-H.
The deer I've taken with the Berger VLDH bullet have been deadly.
However, one was a doe taken at ~65 yards, and the shot was behind the shoulder. The shot impacted near side behind the shoulder, exiting off side behind off-side shoulder (entrance and exit were both in the ribs). The bullet exit was actually two holes, indicating the bullet came apart in at least two major portions. Exit holes were both combined the size of my fist (side by side). That doe traveled ~70 yards, leaving a massive blood trail. The gun used was a T/C Encore 30-338WM handgun with a 16.5" bbl. MV was 2700 FPS with a Berger 175 VLDH bullet (normally I load this one at 2846 FPS, but slowed it down for increased brass life).
Another deer, a small buck, was shot a 41 paces using a T/C Encore 30-06AI 15"bbl handgun. Muzzle velocity was 2650 FPS. Bullet was a Berger 168 VLDH. That bullet entered behind the near side shoulder (deer was quartering towards me), blowing up inside the deer and never exiting. I found bullet fragments all the way back to the rectum of that deer. He dropped in his tracks, then proceeded to try to drag himself for about 10 feet before expiring.
Another deer was a good size mature 7pt whitetail buck. Taken using a 300 RUM with a Berger 210 VLDH at 3144 FPS MV. This buck was shot at 82 yards, behind the shoulder in the rib cage, and the bullet exited the offside in the rib cage. However, the deer dropped in his tracks like a sack of potatoes. The bullet, with out impacting the spine, broke the deer's back - just like snapping a stick over your knee - likely from the hydrostatic shock. I was expecting a rather large exit hole, but it was rather unimpressive. However, that buck never knew what hit him (he was chasing a doe - and the doe wasn't ready for him to quit chasing her, as she hung around waiting on him to get back up and get after her - she finally eased over there and sniffed of him, then slowly walked away).
So, in summary, I'd still shoot for the shoulder even with the Berger, just to try to anchor the deer on the spot.