When myself and 2 others decided we wanted something on the 300WSM case, we looked at case capacity first to the shoulder knowing full well we were NOT going to change it, just necking down the case first to 25 and 6.5. We had a lot of trouble finding powders we thought would work. There was no 7mm or 270 versions at that time. We started with powders like H4831, RE22 and 7828 that I had left knowing full well when it was gone there wasn't anymore to be had, but it gave us good data over the pressure trace.
All the powders tested, except 7828, were poor performers, so we stepped it up to RE25 firstly, then Supreme 780, the only true slow powders available to us then, later H1000 and RETUMBO became available and data went up again.
Initial data was taken from 300WSM loads reduced by 10%, but we had hangfires, dented case shoulders and strange anomalous pressure excursions. It wasn't until Quickload came about that we could choose a powder and run it and see rough results before we fired a shot. We also played with a 338 version but it didn't even come close to the 338WM and left it alone. A 35 cal was developed by a mate of mine, he called it the 35Sambar and it got pretty good results compared to the 338 version.
So, I would recommend getting QL and running your ideas through it to see what sort of results, good or bad, before delving into designing your brass. It helped me hugely to develop my 338-416 Rigby Improved 45° and 375-416 Rigby Improved 40° cases.
Cheers.