The 53s — wonderful as they are — won't stabilize in the 1:14" or slower twist-rate barrels, which almost all store-bought .22 CFs come with (unfortunately.)
My nice Swift and Remington .22-250 sit in the safe most of the time because of that, while I shoot the cheap Savage FV I bought just because it has a 1:12; it's quite accurate with either the 55 or 53 V-Maxes. I shoot mostly groundhogs, and the 53s seem to splatter a wee bit more at longer distances — where they buck the wind better, too.