I had a rifle built with the idea of a subsonic/suppressed .510 caliber, mostly for the 750 Amax. If you do the numbers, with the high BC Amax it will loose little velocity out to 500 yards. Some will say that you will not get much terminal performance out of a bullet that slow and no expansion. However, if people do fine with large cast bullets out of smaller cartridges then how can you argue with a bullet that is already the size (or larger) than most expanded hunting bullets. It'll knock a large hole through about anything, just won't get the temporary wound and shock of a high velocity projectile. I have shot the Amax into wet media and found that the tips will come off or deform and maybe cause a larger wound, but they weren't consistent enough to count on. They are too expensive to just go out and do a lot of shooting with. If you want some extremely good terminal performance look into the Lehigh subsonic fracturing bullets. The front 1/3 of the bullet will fracture into large petals and the large rear shank will penetrate like no one's business.