I have a 45-120, it has been a long time since I have loaded any of my ammo, but I used Clean Shot back then, don't think that is available anymore, but any black powder will do. I used 500gr. Hornandy .458 Soft nose, they we're the most accurate. Basically, you load the black powder to the point of touching the base of the bullet, with my setup, it was with 100gr of Clean shot, you can try Pyrodex I used it as well. You can try the Pyrodex pellets, but you may need to add wadding in the case so there is no open space between bullet and powder. Good luck and have fun, I just hated cleaning mine. I have the David Pedersolli Quigley rifle.