From my experience, if you do not have a pass through with bullets larger than .224 and 100 grains on white tail, the largest culprit is shot placement. When bullets don't exit they're dumping all of their energy inside of that animal, and usually on whitetail sized game, its a devastating wound channel, and even more so with magnum calibers.
I had sever bad experiences with Axis bucks and whitetail bucks with the 178 ELDX passing through and not expanding much. When stepping up to magnum calibers, I've had decent results with the 212 eldx, in a 300 wm, muzzle velocity of 2,985 fps.
Here is a blackbuck doe I shot on the run at 200 yards. Not the best shot but the animal dropped and obviously the bullet expanded.
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I'm a huge fan of eldms for hunting game under 300 pounds. Below I shot a 200 lb whitetail buck with my 30 SM, 200 yards, 225 eldm, muzzle velocity of 2,850 fps (20" barrel). The buck was quartering away, entered in the ribs and did not exit. If it would of exited it would of been in the chest cavity. The buck went 20 yards and rolled over. Internals were liquified as the animal absorbed all of the bullets energy.
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When the opportunity arises, my go to shot placement on exotics, WT, etc is going to be dead center mass of the shoulder. You'll likely hit bone and have decent expansion, and it allows for margin of error.