People say I have split personalities and I am about to display them.
280AI will run very close to the Nosler in speed depending on your definition of close AND your barrel. Could well be 100 FPS or 300 depending on the barrel so its kind of a crapshoot. The Nosler is over the efficiency level in 7mm, it will burn more powder (DUH) and will tear a throat up faster.
The Nosler WILL outrun the 280AI. At 387 yds it probably wont matter. Probably wont matter at 1200 either if you do your job, HOWEVER miss the range or air density by much and the Nosler may save your bacon. Same thing with wind, do your job and its the same....miss the wind call and the Nosler COULD save you. I am a big case kinda guy and that extra 1" CAN make a difference.
That's the ballistics part of it...now for the rest.
280AI brass is cheaper and made by more than 1 company. What do ya do if your rifle and Nosler brass don't get along? Cut off some RP? Good luck finding that. Nosler brass also you need to buy enough from 1 lot to kill your barrel as different lots will be weight sorted and likely very different in weight. 280 brass.....EVERYONE makes it or 06 even Lapua.
The recent issues with availability of the RUMs, SAUMs and WSSMs has made me look at brass availability in a lot different manner. I was shooting EVERYTHING based off of these cases. Now they are hard to find and PER SHOT more than Lapua AND less consistent. I have been cured of buying American made NICHE brass PERMANENTLY. Went to the 338 Lapua after 5+ Edge barrels and am going to replace my smaller stuff with stuff I can buy Lapua brass for. I loved working with the RUM, SAUM and WSSM when you could walk in and buy brass for $1 a pop and weight sort down to 40 out of 50. Nosler brass has been too soft FOR ME though others say its not. Of course I run it with a lot of Retumbo and 300gr SMKs so take that with a grain of salt.
Choose the 280AI and you will have a SAFE great performing rig out to 1500. By safe I mean less likely to have weird issues or component problems.
Choose the Nosler and it might save you on a LR shot where inches CAN count even when they shouldn't.
OR chamber for the 280AI AND if its not 100% everything you wanted.....rechamber to 28 Nosler. Can't go the other way.
I vote 280AI.