I would guess it is neck to neck with the 22-250ackley. I've been shooting a slow 14 twist Ackley for a few years now. It is a great predator round and absolutely blows prarie dogs to shreds. I'm shooting 50 grain z-max's at 4,000 fps. Hard on barrels, especially in a good dog town. My barrel is right at 1,000 rounds and is toast, but to be fair I've ran it hard several times shooting till I couldn't touch the barrel. If I wasn't set up for the Ackley I would build a 22 Creed with a 7 or 8 twist barrel. I have one more 14 twist setting on the bench to burn up then it's on to the 8 twist Rock setting next to it.