I have several 30 cal rifles, including a 30-378 Weatherby. Plenty of powder for good velocity, but only a 1:10 twist rate. My groups have been a little too inconsistent, and I'm wondering if a 1:10 twist rate is fast enough to stabilize the bullet. I haven't tried a full pallet of powders yet, but N217, H1000, and Reloader 33 have not always yielded the greatest groups. Sometimes yes....sometimes no, and I'm not sure it isn't just "luck of the draw" sometimes.