Hi LLoyd,
rl17 would probably be a good choice in the 25-06 with up to 100 grain pills. My pops is using I 4831 in his 25-06 with 100's and it's been great.
Remington 3.224 CCI 200
Reloder 25 58 3,071
the above is a load from the alliant web site for the 25-06.
I don't have a 25-06 but I've played with both rl22 and rl25 in my 25 wssm. It burns just fine and pushes well, but I couldn't get accuracy with either powder. I was getting speeds I won't publish with rl22 in my wssm; all I'll say is easy extraction and Roy would have been ****ed. rl25 was compressed and made 3K fps easily with 120's; this barrel likes light loads though so she was pitching about 2moa with rl25.
I finally settled on 4895(or v550) with 100's and h4350 with 120's. I've recently begun using Superformance, and while a bit finickey, it'll haul well with 3300 fps on tap out of the little wssm with 100's.