I have Winchester, CCI and Federal all in large rifle magnum. Don't ask because I removed all the guns, silver and gold bullion from the safe and replaced them with my primers. The only "real" difference that I found was that the Winchester primers seemed to have hard anvils and sometimes I would get a fail to fire from them. I don't know it is just this batch or something that is characteristic with Winchester primers. As for difference in performance I have not experienced any difference. I did read in one of the replies that if your load is at maximum or even close to it I would recommend dropping the load and working up to it slowly.