Powder is a major factor. Don't get attached to a powder. My rule is start at a safe charge and go up .5GR until it shoots. If it doesn't aquire precision before you reach preasure or case fill change powder accordingly. Finding a powder that gives a wide precision mark on multiple grains of powder is optimal. Recheck gun cold and at distance to make sure load is stable in a cold gun. I had this with a 7PRC recently. I have had great luck with retumbo so that is where I started. The new 151 OSN proto showed no sighns through loading and with very little data on bullet had me questioning if there was a problem with bullet. I forced myself to go with N560 and it had a 2GR mark where it shot same point of impact and all 12 rounds would have basically fit into a .5MOA. The powder is where I would look to first. 300PRC I would try that with n560, H4831sc, N565, Retumbo to start with a .001-.0005 mandrel and see how that goes. The one place I have seen to be a major problem with our bullets is if a barrel is oversized. I have seen a few of them now and they can be very frustrating. Copper solids seem to be affected more by this than a lead cut and core. During development you will see 15-25fps increase per .5GR and closer you get to preasure that will increase. Around 1-2GR below first felt preasure you that will increase by 50+ fps and I usually find my best load in this window. On a loose barrel you will not see this preasure window. It will just increase 15-25fps through development until it hits preasure and there will be no ryme or reason to group size. Let me know if this helps and if I can help in any way.
Below is the first spot the 7prc shot and 1.5-2GR later.

