One of my favorite "bad weather" shooting lanes is 483 yards long, and they have a habit of walking out most often either in the 70-100 range or at 400+. The higher the starting velocity, the easier the wind is to manage at the far end. And then, just in general I have locations that stretch beyond any practical limit; stalking closer is the usual solution, but long range options are nice for when getting closer before running out of opportunity, or light isn't possible. . . Then there are those lucky days when a nice buck will appear out of no-where, somehow already within 40 yards of me; can't pass those up just because I'm carrying my "long range" rifle; but it would be nice if I didn't destroy them too badly.
Looking at various 6.5s other's have here, it seems 3100fps at the muzzle should be doable with the 142/143s, so bullets are going to be still cooking along pretty hot until they get past the first 200 yards, but they'll still hit decently hard at 500.
No bullet is perfect at point blank and max range . . . but some are better than others, and I'm just trying to sort out how the new generation of high BC offerings are working out for people before deciding what path to take.