I'll show you pictures of a ballistic calculator for example. It will be same elevation, but different temps and pressure for say a snowy, 15° day and a warmish, 65° sunny day. These are changes you will encounter. Very easy swing here in Wyoming during elk season....

These two are with pressure, temp, and humidity from a 15° cold day, snowy or foggy, and low pressure.

And these are the same location, same ranges, same gun and load, but a pleasant 65°, sunny, high pressure low humidity day. At 500, there is a difference of .5 MOA in impacts in the two days, or 2.62". So, still close enough for hunting purposes. However, at 850 yards, the difference is still .5 MOA, but impacts differ by 4.45", and this is with a highly efficient load (147 eld-m @3040 fps) if you are shooting something less efficient, the differemce will be more.

Now, you can help yourself out by finding the median temperature, elevation, station pressure, humidity, ect., and use that to calibrate your turret, and you will be close. Still though, wind direction can effect this in a significant mannor, cross vs. Head vs. Tail, and it all adds up. Plus left or right wind with spin drift added to your left to right but subtracted from your right to left.....if your shooting past 500 or so, just use a calculator and input an exact number to your turrets to ensure a good hit. This 500 number can increase or decrease based on a few things, are conditions close to your calculated turret, is there very little wind, ect.

You will have to use your best judgement, but generally, if you are 500 or farther from a critter, you will have the extra 30 seconds to 1 minute to use your phone app to get an exact dope. We strive for good first round impacts, give yourself every chance you can.