I have the 70NBT's flying GREAT out of my 1 in 10 twist 243 win., using 48.1 Reloader 19 and CCI BR2 primers at just 2.620". I'm playing with the 75 V-MAX's right now and so far, it looks like 42.3 of Reloader 15 lit by a Fed210 primer is going to be the winner. This one may be approaching "warm" though, so start down around 39 or so and work up in your gun. The 70NBT's RL 19 load above is flying at about 3,250fps whereas I had a Varget load for these (42.8) that was up around 3,500. I've shot as high as 41.5 of Varget with the 75's, and 42.9 of RL15 with the 75's - with no real pressure signs in either case (yet), but it was also pretty cold out. And 42.9 was, I thought anyway, just starting to give me a little tighter bolt lift so didn't go any further. Just take is slow.
My rifle loved Hornady Custom Ammo in 58 V-MAX, but I was never able to find a perfect load for these. I also have a 22-250 that shoots 52's & 55's lights out, so I decided to move on up in the 243 to find something that would be better in wind. 85's, 80's, 70's, now these 75's. Good luck.