The harmonious marriage relationship between a load and a rifle requires that all physical factors be in balance. Caliber, barrel twist rate, chamber dimensions, bullet weight, bullet BC, powder charge, primer type, rifle action and bore condition, bullet seating depth, OAL, etc. Something as simple as an unsuitable twist rate can make load development with a particular bullet essentially impossible. There are a lot of questions to be answered here before any real problem analysis can take place.