I've never shot the big PD's but I've shot a lot of Gophers/Ground Squirrels. It's hard to pick a favorite but the easy button is the Practical...just neck down some LC range brass and go shoot! I had a seasoned varmint shooter tell me once "They're like golf clubs you need a few for different distances!"
The .20's are where it's at, on a 2 day Gopher trip last year I took a buddy for his first time and he put together a 20 Practical right before we went but also brought his 223 bolt gun...he enjoyed shooting the Practical so much he never even put a round through the 223 and on the way home ordered everything to build a 20 PPC...LOL
My rifles,
Rem 7 300BO action, 24" Pac-Nor in 11 twist barrel in 20 VarTarg shooting 32gr Varmageddon or 32gr V-Max @ 3800
Savage 12FV action, 24" Shilen 12 twist barrel in 20 PPC shooting 40gr V-max @ 3900
Savage 12FV action, 24" X-Caliber 11 twist barrel in 20 Practical shooting 32gr Varmageddon @ 4300
Impact NBK action, 24" X-Caliber 9 twist barrel in 20 BR shooting 55gr Bergers @ 3600